Supplement × Prescription·a conflict·Emerging evidence
St. John's Wort can induce CYP3A4 and may reduce solifenacin exposure, decreasing bladder symptom control.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can induce CYP3A4 and may reduce solifenacin exposure, decreasing bladder symptom control.
Mechanism. CYP3A4 induction can lower exposure to CYP3A4 substrates.
Recommendation. Avoid starting or stopping St. John's Wort without discussing symptom monitoring and alternatives.
Effect on the composite score
If both Solifenacin and St. John's Wort are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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