NutriStack
CautionEmerging evidence
What is happening. Melatonin may add to solifenacin-associated somnolence or dizziness.
Mechanism. Additive CNS depressant effects.
Recommendation. Use cautiously in older adults and avoid hazardous tasks if sedated.
Supplement × Prescription·a caution·Emerging evidence
Melatonin + Solifenacin
Caution
Emerging evidence
Melatonin may add to solifenacin-associated somnolence or dizziness.
From the database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Substances
Melatonin and Solifenacin
Pair type
Caution
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Stack Score
How it moves the number.
Effect on the composite score
If both Melatonin and Solifenacin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Sources
Sources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1American Urological Association. AUA/SUFU Guideline on Idiopathic Overactive Bladder. 2024.Needs sourceNo link
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