NutriStack
Vitamin B9 and Vitamin C, a synergy.
Vitamin C protects folate from oxidative degradation and helps maintain it in its reduced, active form.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin B9 and Vitamin C
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Vitamin C protects folate from oxidative degradation and helps maintain it in its reduced, active form.
Mechanism. Ascorbic acid maintains tetrahydrofolate (THF) in its reduced form by preventing oxidation to dihydrofolate. This preserves folate coenzyme activity for one-carbon metabolism.
Recommendation. Take together. Vitamin C preserves folate stability in the blood and tissues.
Sources (2)
- Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. 2000
- Bayu P, Wibisono JJ. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials.. PLoS One. 2024. PMID 38820340
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin B9 and Vitamin C are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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