NutriStack
Symptom·Appearance·Reviewed May 30, 2026
Supplements for Age spots / hyperpigmentation.
When age spots / hyperpigmentation is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Vitamin CModerate80% match
Vitamin C inhibits tyrosinase and limits melanin formation while protecting against oxidative pigment triggers.
SuggestedTopical L-ascorbic acid serum (10 to 20 percent) - 02L-GlutathioneLimited68% match
Glutathione may shift melanin synthesis toward lighter pigment and quench oxidative stress, with some support for skin lightening.
SuggestedTopical or liposomal L-glutathione - 03Pine Bark ExtractLimited64% match
Pycnogenol antioxidants have reduced melasma pigmentation in small oral trials.
SuggestedStandardized pine bark extract (Pycnogenol) - 04AstaxanthinLimited60% match
This carotenoid antioxidant may reduce UV-driven pigment formation and improve skin tone in some studies.
SuggestedAstaxanthin (4 to 12 mg) softgel - 05Vitamin ELimited55% match
Vitamin E is a lipid-soluble antioxidant that may complement vitamin C in limiting oxidative pigmentation.
SuggestedMixed tocopherols (paired with topical C)
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