Symptom·Metabolic·Reviewed June 4, 2026
Supplements for Difficulty losing weight.
When difficulty losing weight is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01EGCG (Epigallocatechin Gallate)Moderate55% match
EGCG inhibits catechol-O-methyltransferase (COMT), which slows the breakdown of norepinephrine and modestly prolongs sympathetic stimulation of thermogenesis and fat oxidation. Effects on energy expenditure and body weight are small and mo...
SuggestedStandardized green tea catechin extract (decaffeinated or with caffeine), commonly 270-450 mg EGCG daily in divided doses with food - 02FucoxanthinLimited50% match
In rodent models fucoxanthin upregulates uncoupling protein 1 (UCP1) in white adipose tissue, promoting thermogenesis and fatty-acid oxidation. A small human trial of a fucoxanthin/pomegranate-seed-oil combination reported modest reduction...
SuggestedStandardized brown-seaweed (Undaria pinnatifida) extract, typically supplying 2.4 to 8 mg fucoxanthin daily, taken with a fat-containing meal to aid absorption
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