Symptom·Cognitive·Reviewed June 4, 2026
Supplements for Mental fatigue.
When mental fatigue is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Panax GinsengModerate65% match
Ginsenosides (notably Rb1 and Rg1) modulate central cholinergic and dopaminergic signaling and improve cerebral glucose utilization, which may reduce subjective mental fatigue and sustain performance during prolonged cognitively demanding...
SuggestedStandardized root extract (e.g., G115) providing roughly 4 percent ginsenosides, about 200 to 400 mg daily - 02American GinsengLimited60% match
As an adaptogenic ginsenoside source, American ginseng may modulate the HPA axis and support cerebral energy metabolism, with trial evidence of improved sustained attention and reaction time on cognitively demanding tasks shortly after dos...
SuggestedStandardized extract 100-200 mg
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