NutriStack
Symptom·Musculoskeletal·Reviewed May 30, 2026
Supplements for Muscle weakness / age-related muscle loss.
When muscle weakness / age-related muscle loss is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01CreatineStrong88% match
Creatine increases muscle phosphocreatine stores and, combined with resistance training, reliably improves strength and lean mass in older adults.
SuggestedCreatine monohydrate - 02Vitamin D3Strong80% match
Vitamin D supports muscle fiber function and strength, and correcting deficiency reduces falls and weakness in older adults.
SuggestedD3 (cholecalciferol) - 03HMBModerate70% match
HMB, a leucine metabolite, may slow muscle protein breakdown and help preserve lean mass during aging or periods of low activity.
SuggestedCalcium HMB - 04Magnesium GlycinateModerate62% match
Magnesium is required for muscle contraction and energy metabolism, and low status can contribute to weakness and cramping.
SuggestedMagnesium bisglycinate - 05Fish OilLimited60% match
Omega-3 fatty acids may enhance the muscle protein synthesis response to protein and training in older adults, though effects are modest.
SuggestedHigh-EPA/DHA fish oil - 06BCAAsLimited56% match
Branched-chain amino acids, especially leucine, signal muscle protein synthesis, though whole protein is generally more effective for muscle preservation.
SuggestedLeucine-weighted BCAA powder
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