NutriStack
Symptom·Musculoskeletal·Reviewed May 30, 2026
Supplements for Nocturnal leg cramps (night-time calf and foot cramps).
When nocturnal leg cramps (night-time calf and foot cramps) is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Magnesium GlycinateLimited84% match
Magnesium supports normal neuromuscular excitability and may reduce the frequency of involuntary muscle contractions during sleep.
SuggestedMagnesium glycinate, 200 to 400 mg elemental taken in the evening - 02Magnesium CitrateLimited74% match
Provides bioavailable magnesium to support neuromuscular function when dietary intake is low.
SuggestedMagnesium citrate, 200 to 300 mg elemental in the evening - 03PotassiumLimited62% match
Adequate potassium maintains the electrolyte gradients that govern muscle relaxation and contraction.
SuggestedPotassium from diet first; low-dose supplement only if intake is poor - 04Vitamin B12Limited55% match
Corrects a deficiency that can cause nerve hyperexcitability contributing to cramping in older or vegan adults.
SuggestedMethylcobalamin, 1000 mcg daily - 05Vitamin D3Limited50% match
Adequate vitamin D supports calcium handling and neuromuscular function, and low levels are associated with muscle complaints.
SuggestedVitamin D3, 1000 to 2000 IU daily with a meal - 06TaurineLimited42% match
Taurine modulates calcium flux and membrane stability in muscle, which may temper involuntary contractions.
SuggestedTaurine, 1 to 2 g in the evening
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