NutriStack
Alpha-Lipoic Acid and Lisinopril, a synergy.
Alpha-Lipoic Acid lowers blood pressure modestly and improves endothelial function. The QUALITY study found that the blood pressure and endothelial benefits of alpha-lipoic acid were strongly potentiated when combined with the ACE inhibitor quinapril in diabetic patients with stage 1 hypertension. The combination is well tolerated; mild hypotension is possible.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-Lipoic Acid and Lisinopril
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Alpha-Lipoic Acid lowers blood pressure modestly and improves endothelial function. The QUALITY study found that the blood pressure and endothelial benefits of alpha-lipoic acid were strongly potentiated when combined with the ACE inhibitor quinapril in diabetic patients with stage 1 hypertension. The combination is well tolerated; mild hypotension is possible.
Mechanism. Alpha-lipoic acid scavenges reactive oxygen species, regenerates other antioxidants, and increases nitric oxide bioavailability in endothelial cells. ACE inhibition independently raises bradykinin and nitric oxide. The combined endothelial effects are amplified.
Recommendation. Alpha-Lipoic Acid 300-600 mg/day is a typical research dose; monitor home blood pressure after starting and tell your prescriber so your lisinopril dose can be reviewed. Best taken on an empty stomach.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Lisinopril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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