NutriStack
Amiodarone and Magnesium Glycinate, a synergy.
Amiodarone can prolong cardiac repolarization, and low magnesium makes torsades de pointes more likely. Maintaining normal magnesium status helps stabilize repolarization and supports potassium balance. Oral magnesium is preventive support when intake is low; acute torsades requires emergency care and intravenous magnesium.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amiodarone and Magnesium Glycinate
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Amiodarone can prolong cardiac repolarization, and low magnesium makes torsades de pointes more likely. Maintaining normal magnesium status helps stabilize repolarization and supports potassium balance. Oral magnesium is preventive support when intake is low; acute torsades requires emergency care and intravenous magnesium.
Mechanism. Magnesium suppresses early afterdepolarizations and helps maintain intracellular potassium. Hypomagnesemia lowers repolarization reserve, increasing susceptibility to QT-drug-induced torsades.
Recommendation. Maintain adequate magnesium intake while taking amiodarone, especially if you also take diuretics, PPIs, or have diarrhea. Ask your prescriber about checking magnesium periodically, and do not use high-dose magnesium if you have significant kidney disease unless monitored.
Sources (2)
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139-152. PMID 27212965
- Yau S, Chan P, Sapkin J, Hsieh E. Short-term use of oral amiodarone causing torsades de pointes. Clin Case Rep. 2018;6(8):1554-1556. PMID 30147903
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amiodarone and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.