What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Berberine + Tangeretin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a caution·Emerging evidence

Berberine + Tangeretin

Q: Can I take Berberine and Tangeretin together?

Possibly, but with caution. Berberine and Tangeretin have a documented caution-tier interaction. Tangeretin is a recognized inhibitor of cytochrome P450 enzymes (notably CYP1A2 and CYP3A4), and berberine also inhibits CYP3A4 and CYP2D6, so combining them may compound effects on the metabolism of co-administered drugs.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Tangeretin is a recognized inhibitor of cytochrome P450 enzymes (notably CYP1A2 and CYP3A4), and berberine also inhibits CYP3A4 and CYP2D6, so combining them may compound effects on the metabolism of co-administered drugs.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Berberine and Tangeretin

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Tangeretin is a recognized inhibitor of cytochrome P450 enzymes (notably CYP1A2 and CYP3A4), and berberine also inhibits CYP3A4 and CYP2D6, so combining them may compound effects on the metabolism of co-administered drugs.

Mechanism. Polymethoxylated flavones such as tangeretin inhibit CYP1A2 and CYP3A4 in the gut and liver; berberine adds CYP3A4 and CYP2D6 inhibition. Combined enzyme inhibition can raise plasma concentrations of certain prescription substrates.

Recommendation. The two supplements together are generally tolerated, but use caution if you also take narrow-therapeutic-index medications metabolized by CYP3A4 or CYP1A2 and consult a clinician or pharmacist.

Stack Score

How it moves the number.

Effect on the composite score

If both Berberine and Tangeretin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Guo Y, et al. Repeated administration of berberine inhibits cytochromes P450 in humans. European Journal of Clinical Pharmacology. 2012.Needs sourceNo link

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