NutriStack
Coenzyme Q10 and Lisinopril, a synergy.
Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A meta-analysis of 12 clinical trials reported systolic reductions of up to 17 mm Hg with CoQ10. When added to an ACE inhibitor like lisinopril, the effect is generally additive and well tolerated, which can be helpful for patients with residual hypertension or heart failure.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Coenzyme Q10 and Lisinopril
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A meta-analysis of 12 clinical trials reported systolic reductions of up to 17 mm Hg with CoQ10. When added to an ACE inhibitor like lisinopril, the effect is generally additive and well tolerated, which can be helpful for patients with residual hypertension or heart failure.
Mechanism. CoQ10 improves mitochondrial function in vascular smooth muscle and endothelium, increases nitric oxide bioavailability, and reduces oxidative inactivation of endothelium-derived relaxing factors. These effects complement ACE inhibition.
Recommendation. If your blood pressure is well controlled on lisinopril alone, monitor at home before adding CoQ10 to avoid hypotension. A typical dose is 100-200 mg/day with a fat-containing meal. Recheck blood pressure within 2-4 weeks and tell your prescriber so any lisinopril dose adjustment can be made.
Sources (2)
- Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007;21(4):297-306. PMID 17287847
- Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J. 2001;94(11):1112-7. PMID 11780680
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 and Lisinopril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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