NutriStack
Coenzyme Q10 and Pravastatin, a synergy.
All statins reduce CoQ10 levels by inhibiting the mevalonate pathway. Pravastatin has lower myopathy risk but still depletes CoQ10. Supplementation may benefit patients with muscle complaints.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Coenzyme Q10 and Pravastatin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 5 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. All statins reduce CoQ10 levels by inhibiting the mevalonate pathway. Pravastatin has lower myopathy risk but still depletes CoQ10. Supplementation may benefit patients with muscle complaints.
Mechanism. Pravastatin inhibits HMG-CoA reductase, reducing mevalonate-derived CoQ10 biosynthesis. Although pravastatin is hydrophilic with lower muscle penetration, CoQ10 depletion still occurs.
Recommendation. CoQ10 100-200mg/day may help with muscle symptoms on pravastatin. Does not interfere with lipid-lowering efficacy.
Sources (5)
- Banach M et al. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis. Mayo Clin Proc. 2015;90(1):24-34. PMID 25440725
- Tsai IC, Hsu CW, Chang CH et al.. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Frontiers in Pharmacology. 2022. PMID 36091835
- Liu Z, Tian Z, Zhao D et al.. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.. Journal of Clinical Endocrinology and Metabolism. 2022. PMID 36337001
- Hou S, Tian Z, Zhao D et al.. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.. Molecular Nutrition & Food Research. 2023. PMID 37118903
- Sazali S, Badrin S, Norhayati MN et al.. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis.. BMJ Open. 2021. PMID 33402403
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 and Pravastatin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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