NutriStack
Fish Oil and Lisinopril, a synergy.
Fish Oil reduces blood pressure modestly (about 3/1.5 mm Hg in hypertensives) and has independent renoprotective effects through suppression of ACE activity, reduced angiotensin II formation, and downregulation of TGF-beta. Combined with lisinopril the effects are additive and well tolerated, with potential benefit in proteinuria.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fish Oil and Lisinopril
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Fish Oil reduces blood pressure modestly (about 3/1.5 mm Hg in hypertensives) and has independent renoprotective effects through suppression of ACE activity, reduced angiotensin II formation, and downregulation of TGF-beta. Combined with lisinopril the effects are additive and well tolerated, with potential benefit in proteinuria.
Mechanism. EPA and DHA suppress ACE activity, reduce angiotensin II generation, increase endothelial nitric oxide, and reduce TGF-beta-mediated renal fibrosis. These actions complement and reinforce ACE inhibition.
Recommendation. Fish Oil 1-3 g/day of combined EPA+DHA is a reasonable add-on; monitor home blood pressure after starting and tell your prescriber. Higher doses (greater than 3 g/day) may modestly raise bleeding risk.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Lisinopril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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