NutriStack
Fish Oil and Serrapeptase, a caution.
Fish oil has mild antiplatelet activity that can add to serrapeptase's fibrinolytic effect, modestly increasing the chance of bruising or prolonged bleeding, mainly at high omega-3 doses or around surgery.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fish Oil and Serrapeptase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Fish oil has mild antiplatelet activity that can add to serrapeptase's fibrinolytic effect, modestly increasing the chance of bruising or prolonged bleeding, mainly at high omega-3 doses or around surgery.
Mechanism. Omega-3 fatty acids incorporate into platelet membranes and shift eicosanoid balance toward antiplatelet prostacyclin, which can be additive to serrapeptase's fibrin-degrading, mild antiplatelet effect.
Recommendation. The combination is generally tolerated, but use caution with high-dose fish oil. Discontinue both before surgery and consult a clinician if also taking antiplatelet or anticoagulant medication.
Sources (2)
- Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. PMID 32104332
- Javaid M et al. Bleeding Risk in Patients Receiving Omega-3 Polyunsaturated Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Am Heart Assoc. 2024;13(10):e032390. PMID 38742535
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Serrapeptase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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