Interaction databaseSupplement × SupplementReviewed May 2026

Ginkgo Biloba and Serrapeptase, a caution.

Ginkgo inhibits platelet-activating factor and serrapeptase is fibrinolytic, so combining them can additively impair hemostasis and increase the risk of bruising and bleeding.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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At a glance

Substances
Ginkgo Biloba and Serrapeptase
Pair type
Caution
Evidence (highest tier)
Emerging
Source citations
2 sources
Stack Score effect
−5 to your Stack Score (per scored caution row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Ginkgo inhibits platelet-activating factor and serrapeptase is fibrinolytic, so combining them can additively impair hemostasis and increase the risk of bruising and bleeding.

Mechanism. Ginkgo terpenoids (ginkgolides) antagonize platelet-activating factor and reduce platelet aggregation, while serrapeptase breaks down fibrin and has reported antithrombotic effects, producing an additive reduction in clotting capacity.

Recommendation. Combine cautiously and monitor for bleeding signs. Avoid the combination with anticoagulants or antiplatelet drugs unless supervised, and stop both at least 7 to 10 days before surgery.

Sources (2)
  1. Bone KM. Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence? Mol Nutr Food Res. 2008;52(7):764-71. PMID 18214851
  2. Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. PMID 32104332

Stack Score

How this pair moves the number.

Effect on the composite score

If both Ginkgo Biloba and Serrapeptase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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