Supplement × Prescription·a synergy·Moderate evidence

Haloperidol + Potassium

Synergy Moderate evidence

Hypokalemia increases risk of QT-related ventricular arrhythmias during haloperidol therapy.

From the database

What the row says.

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Substances
Pair type
Synergy
Evidence
Moderate
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyModerate evidence

What is happening. Hypokalemia increases risk of QT-related ventricular arrhythmias during haloperidol therapy.

Mechanism. Normal potassium reduces delayed repolarization and torsades vulnerability.

Recommendation. Correct hypokalemia medically and avoid unsupervised potassium supplementation in kidney disease or with potassium-retaining drugs.

Stack Score

How it moves the number.

Effect on the composite score

If both Haloperidol and Potassium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Haloperidol tablets US Prescribing Information. 2025.Needs sourceNo link

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