NutriStack
L-Citrulline and Pine Bark Extract, a synergy.
L-citrulline raises plasma arginine and nitric oxide production, complementing pine bark extract's enhancement and protection of endothelial nitric oxide signaling.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Citrulline and Pine Bark Extract
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. L-citrulline raises plasma arginine and nitric oxide production, complementing pine bark extract's enhancement and protection of endothelial nitric oxide signaling.
Mechanism. L-citrulline is converted to arginine and then nitric oxide via NOS, while pine bark procyanidins upregulate eNOS and reduce oxidative breakdown of NO, jointly boosting endothelial NO availability.
Recommendation. A rational vascular-support pairing. Those on antihypertensives should watch for additive blood-pressure lowering.
Sources (2)
- Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics, 2002
- Schwedhelm E et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology, 2008
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Citrulline and Pine Bark Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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