Interaction databaseSupplement × PrescriptionReviewed May 2026

Lisinopril and Magnesium Taurate, a synergy.

Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic reductions in hypertensives. The taurate form combines magnesium with taurine, both of which have independent cardiovascular and blood-pressure-lowering effects. Combined with lisinopril the effects are additive and generally well tolerated.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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At a glance

Substances
Lisinopril and Magnesium Taurate
Pair type
Synergy
Evidence (highest tier)
Moderate
Source citations
2 sources
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Prescription
Last verified
May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic reductions in hypertensives. The taurate form combines magnesium with taurine, both of which have independent cardiovascular and blood-pressure-lowering effects. Combined with lisinopril the effects are additive and generally well tolerated.

Mechanism. Magnesium modulates vascular smooth muscle calcium handling, promotes nitric oxide release, and inhibits angiotensin-induced vasoconstriction. Taurine independently reduces sympathetic tone. Both add to ACE inhibition.

Recommendation. Magnesium Taurate at doses providing 200-350 mg elemental magnesium daily is a reasonable add-on for blood pressure or cardiovascular support; monitor home blood pressure after starting. Tell your prescriber so your lisinopril dose can be reviewed.

Sources (2)
  1. Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr. 2012;66(4):411-8. PMID 22318649
  2. Militante JD, Lombardini JB. Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids. 2002;23(4):381-93. PMID 12436205

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lisinopril and Magnesium Taurate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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