NutriStack
Lisinopril and NAC, a synergy.
NAC has direct ACE-inhibitory activity (about 30% reduction in ACE activity in vivo) and provides sulfhydryl groups that may amplify nitric-oxide-mediated vasodilation. A small clinical study reported additional blood pressure reduction when NAC 1.2 g/day was added to lisinopril in patients already at goal. The effect is small but the combination is well tolerated.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Lisinopril and NAC
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. NAC has direct ACE-inhibitory activity (about 30% reduction in ACE activity in vivo) and provides sulfhydryl groups that may amplify nitric-oxide-mediated vasodilation. A small clinical study reported additional blood pressure reduction when NAC 1.2 g/day was added to lisinopril in patients already at goal. The effect is small but the combination is well tolerated.
Mechanism. NAC provides sulfhydryl donors that directly inhibit ACE activity and amplify nitric oxide bioavailability by reducing oxidative inactivation. These actions complement lisinopril's effects.
Recommendation. If you are considering NAC (typically 600-1200 mg/day) for other indications while on lisinopril, monitor home blood pressure for additional drops. Tell your prescriber so your lisinopril dose can be reviewed if needed.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lisinopril and NAC are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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