NutriStack
Lisinopril and Spirulina, a synergy.
Spirulina lowers blood pressure modestly in adults (about 3-5 mm Hg systolic and 3-4 mm Hg diastolic in meta-analyses). It also contains meaningful potassium per serving. Combined with lisinopril the blood-pressure effect is additive and well tolerated, but the potassium content warrants attention in patients with kidney disease or diabetes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Lisinopril and Spirulina
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Spirulina lowers blood pressure modestly in adults (about 3-5 mm Hg systolic and 3-4 mm Hg diastolic in meta-analyses). It also contains meaningful potassium per serving. Combined with lisinopril the blood-pressure effect is additive and well tolerated, but the potassium content warrants attention in patients with kidney disease or diabetes.
Mechanism. Spirulina peptides have ACE-inhibitory activity and contribute to nitric oxide-mediated vasodilation. Its modest potassium content does not usually raise serum potassium in healthy kidneys but can contribute in patients with impaired renal handling on ACE inhibitors.
Recommendation. Spirulina 1-4 g/day is the dose range used in trials. Monitor home blood pressure after starting and tell your prescriber. If you have reduced kidney function, diabetes, or take spironolactone, ask your prescriber to check potassium periodically.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lisinopril and Spirulina are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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