NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Calcium and Spirulina: what the published research says

PubMed indexes 8 records that name Calcium and Spirulina together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Spirulina. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Calcium and Spirulina.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effect of Spirulina maxima Supplementation on Calcium, Magnesium, Iron, and Zinc Status in Obese Patients with Treated Hypertension.

Biological trace element research · 2016 · PMID 26779620

Randomized Controlled Trial

“In conclusion, this is the first clinical study on the influence of spirulina supplementation on mineral status in obese patients with hypertension. Spirulina supplementation affects the iron status of obese Caucasians with well-treated hypertension.”

Suliburska et al. · From the abstract

Names both Calcium and Spirulina in its title.

Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis.

The Journal of allergy and clinical immunology · 2016 · PMID 26341274

Observational StudyHuman subjects198 participants

“These data indicate a potential clinical use of Ca-SP containing Spirulina species extract for the prophylactic treatment of herpes labialis and suggest possible activity of Ca-SP against infections caused by other herpesviruses.”

Mader et al. · Authors' conclusion

Names both Calcium and Spirulina in its title.

Identification and characterization of a novel calcium-binding peptide isolated from Spirulina platensis via hydroxyapatite affinity.

Food chemistry · 2026 · PMID 42468422

“Two potential calcium-binding peptides (SGEDAAE and GEDAAEA) were predicted, and further confirmed that hydrogen bonds and hydrophobic interactions exerted effects in the binding process with the calcium-sensing receptor (CaSR). These results offer substantial support for further developing microalgae peptide-based calcium supplements.”

Wang et al. · From the abstract

Names both Calcium and Spirulina in its title.

Open-Label Observational Study of a Topical Formulation of Calcium Spirulan Contained in a Defined Extract of the Microalga Spirulina platensis in the Treatment of Children with Molluscum Contagiosum.

Dermatology research and practice · 2023 · PMID 37564134

“This open-label observational study suggests that a cream formulation containing 1.5% Ca-SP and 1% Spiralin® may be an effective and safe treatment option for children with active MC lesions. The high rate of complete clearance of MC lesions and lack of adverse reactions warrant further investigation in larger, controlled trials.”

Jungclaus et al. · Authors' conclusion

Names both Calcium and Spirulina in its title.

Physiological Performance of Rabbits Administered Buffalo Milk Yogurts Enriched with Whey Protein Concentrate, Calcium Caseinate or Spirulina platensis.

Foods (Basel, Switzerland) · 2021 · PMID 34681542

“Significant improvements appeared in the small intestinal wall, microbiology, growth performance, serum biochemistry, organ histology and meat quality of the group receiving enriched yogurt. Yogurts enriched with WPC, Ca-CN and Spirulina platensis can be used as functional foods.”

Atallah et al. · From the abstract

Names both Calcium and Spirulina in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Spirulina, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.