NutriStack
Lisinopril and Taurine, a synergy.
Taurine lowers blood pressure in prehypertensive and hypertensive adults (about 7 mm Hg systolic in randomized trials) and reduces sympathetic nervous system overactivity. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Lisinopril and Taurine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Taurine lowers blood pressure in prehypertensive and hypertensive adults (about 7 mm Hg systolic in randomized trials) and reduces sympathetic nervous system overactivity. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.
Mechanism. Taurine modulates overactive sympathetic outflow, promotes endothelial nitric oxide via hydrogen sulfide-mediated pathways, and inhibits transient receptor potential channel-induced calcium influx in vascular smooth muscle. These actions complement ACE inhibition.
Recommendation. Taurine 1.5-3 g/day is the dose range used in clinical trials; monitor home blood pressure after starting and tell your prescriber so your lisinopril dose can be reviewed.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lisinopril and Taurine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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