NutriStack
Lithium and Magnesium Glycinate, a caution.
Magnesium may affect lithium excretion and distribution, as both are divalent cations handled by similar renal transport mechanisms. Changes in magnesium status can alter lithium levels. Additionally, lithium can itself cause magnesium wasting.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Lithium and Magnesium Glycinate
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Magnesium may affect lithium excretion and distribution, as both are divalent cations handled by similar renal transport mechanisms. Changes in magnesium status can alter lithium levels. Additionally, lithium can itself cause magnesium wasting.
Mechanism. Magnesium and lithium share renal tubular transport mechanisms. Changes in magnesium intake can alter lithium reabsorption in the proximal tubule. Lithium also inhibits magnesium-dependent enzymes and can increase renal magnesium excretion.
Recommendation. Monitor lithium levels when starting or stopping magnesium supplements. If magnesium supplementation is needed (which it may be, as lithium can deplete magnesium), start at a low dose and have lithium levels checked within 1-2 weeks.
Sources (4)
- Timmer RT, Sands JM. Lithium intoxication. J Am Soc Nephrol. 1999;10(3):666-674. PMID 10073618
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lithium and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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