Supplement × Prescription·a synergy·Moderate evidence
Losartan/Hydrochlorothiazide can lower magnesium in some patients, and magnesium replacement may be needed when deficiency is documented.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Losartan/Hydrochlorothiazide can lower magnesium in some patients, and magnesium replacement may be needed when deficiency is documented.
Mechanism. Diuretic-related urinary magnesium wasting can cause or worsen hypomagnesemia.
Recommendation. Monitor magnesium when clinically indicated and supplement only to a target range, especially in kidney disease.
Effect on the composite score
If both Losartan/Hydrochlorothiazide and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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