Supplement × Prescription·a caution·Moderate evidence
Hydrochlorothiazide decreases urinary calcium excretion; high-dose calcium can contribute to hypercalcemia in susceptible patients.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Hydrochlorothiazide decreases urinary calcium excretion; high-dose calcium can contribute to hypercalcemia in susceptible patients.
Mechanism. Thiazides increase renal tubular calcium reabsorption.
Recommendation. Avoid excessive calcium supplementation and monitor calcium if using high doses or vitamin D, or if kidney disease or hyperparathyroidism is present.
Effect on the composite score
If both Calcium and Losartan/Hydrochlorothiazide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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