Supplement × Prescription·a caution·Strong evidence
Potassium supplements can cause hyperkalemia from losartan even though hydrochlorothiazide can lower potassium in some patients.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Potassium supplements can cause hyperkalemia from losartan even though hydrochlorothiazide can lower potassium in some patients.
Mechanism. Losartan reduces aldosterone-mediated potassium excretion, while hydrochlorothiazide increases urinary potassium loss, so net potassium effect is patient-specific.
Recommendation. Use potassium only with lab monitoring; do not assume the thiazide component makes potassium supplementation safe.
Effect on the composite score
If both Losartan/Hydrochlorothiazide and Potassium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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