NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Olmesartan and Potassium: what the published research says

PubMed indexes 8 records that name Olmesartan and Potassium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Olmesartan and Potassium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Olmesartan and Potassium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Efficacy/safety of olmesartan medoxomil versus losartan potassium in patients by stage 1 or 2 hypertension.

Postgraduate medicine · 2012 · PMID 22691900

Comparative StudyMulticenter StudyRandomized Controlled Trial

“Olmesartan and LOS were well tolerated, and the most common treatment-emergent adverse event was headache. Once-daily, maximum doses of OM in patients with stage 1 or stage 2 hypertension achieved superior BP reductions versus LOS, with similar tolerability.”

Flack et al. · From the abstract

Names both Olmesartan and Potassium in its title.

A randomized, double-blind, forced-titration study to compare olmesartan medoxomil versus losartan potassium in patients with stage 1 and 2 hypertension.

Postgraduate medicine · 2011 · PMID 21293087

Comparative StudyMulticenter StudyRandomized Controlled TrialResearch Support, N.I.H., Extramural246 participants

“Treatment with low- and high-dose OM achieved superior SeBP reductions compared with low- and high-dose LOS, resulting in significantly more patients achieving SeBP goal, with similar tolerability.”

Weir et al. · Authors' conclusion

Names both Olmesartan and Potassium in its title.

Comparison of increasing doses of olmesartan medoxomil, losartan potassium, and valsartan in patients with essential hypertension.

Journal of clinical hypertension (Greenwich, Conn.) · 2007 · PMID 17341994

Multicenter StudyRandomized Controlled TrialResearch Support, N.I.H., Extramural

“Olmesartan did not reduce mean SeDBP significantly compared with valsartan, although more patients attained blood pressure goal with olmesartan (P=.031). At week 12, all agents lowered blood pressure equivalently.”

Giles et al. · From the abstract

Names both Olmesartan and Potassium in its title.

Efficacy and safety of olmesartan medoxomil versus losartan potassium in Chinese patients with mild to moderate essential hypertension

Zhonghua xin xue guan bing za zhi · 2006 · PMID 17217710

Multicenter StudyRandomized Controlled Trial

“This study shows that olmesartan medoxomil, at oral dose of 20 mg-40 mg once daily was effective and safe for hypertension treatment and the hypotensive effect was superior to losartan potassium (50 mg-100 mg once daily).”

Zhu et al. · Authors' conclusion

Names both Olmesartan and Potassium in its title.

Use of 24-hour ambulatory blood pressure monitoring to assess antihypertensive efficacy: a comparison of olmesartan medoxomil, losartan potassium, valsartan, and irbesartan.

American journal of cardiovascular drugs : drugs, devices, and other interventions · 2005 · PMID 15631537

Clinical TrialComparative StudyRandomized Controlled Trial

“ABP goal rates are a meaningful measure of antihypertensive efficacy. The effects on mean change from baseline in ABP and ABP goal rates after 8 weeks of treatment were numerically better, but not statistically significant, for olmesartan medoxomil than for irbesartan. However, olmesartan medoxomil was significantly more effective than losartan potassium or valsartan.”

Smith et al. · Authors' conclusion

Names both Olmesartan and Potassium in its title.

Design, formulation and optimization of novel soft nano-carriers for transdermal olmesartan medoxomil delivery: In vitro characterization and in vivo pharmacokinetic assessment.

International journal of pharmaceutics · 2016 · PMID 27005906

Comparative StudyAnimal study

“The pharmacokinetic study presented that transdermal nano-invasomes formulation showed 1.15 times improvement in bioavailability of olmesartan with respect to the control formulation in Wistar rats. It was concluded that the response surfaces estimated by Design Expert(®) illustrated obvious relationship between formulation factors and response variables and nano-invasomes were found to be a proficient carrier system for transdermal delivery of olmesartan.”

Kamran et al. · From the abstract

Names Olmesartan and Potassium together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Olmesartan, Potassium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.