From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyModerate evidence
What is happening. Beta-2 agonists can lower serum potassium at high exposure, and correcting true hypokalemia reduces arrhythmia risk.
Mechanism. Beta-2 stimulation shifts potassium into cells, while adequate potassium supports cardiac repolarization.
Recommendation. Do not self-treat potassium abnormalities; monitor potassium when high-dose beta-agonists, diuretics, or acute illness are present.
Stack Score
How it moves the number.
Effect on the composite score
If both Potassium and Salmeterol/Fluticasone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Advair Diskus US Prescribing Information. 2026.Needs sourceNo link