Supplement × Prescription·a caution·Strong evidence

Potassium + Tacrolimus

Caution Strong evidence

Tacrolimus can cause hyperkalemia, and potassium supplements or salt substitutes can make levels dangerous.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Strong
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionStrong evidence

What is happening. Tacrolimus can cause hyperkalemia, and potassium supplements or salt substitutes can make levels dangerous.

Mechanism. Calcineurin inhibitor renal tubular effects reduce potassium excretion.

Recommendation. Avoid potassium supplementation unless prescribed and monitored by the transplant team.

Stack Score

How it moves the number.

Effect on the composite score

If both Potassium and Tacrolimus are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Tacrolimus Capsules US Prescribing Information. 2026.Needs sourceNo link

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