NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Potassium and Topiramate: what the published research says

PubMed indexes 8 records that name Potassium and Topiramate together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Potassium and Topiramate. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Potassium and Topiramate.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Chronic impact of topiramate on acid-base balance and potassium in childhood.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2010 · PMID 20005754

Human subjects24 participants

“In patients on topiramate no significant correlation was observed between the dosage of this agent and plasma bicarbonate or potassium as well as between topiramate blood level and the mentioned electrolytes. In conclusion long-term topiramate treatment is associated with a mild, statistically significant tendency towards compensated normal anion gap metabolic acidosis and hypokalemia.”

Belotti et al. · From the abstract

Names both Potassium and Topiramate in its title.

Hypokalemia in Lennox-Gastaut syndrome

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia · 2015 · PMID 26093133

Case ReportsHuman subjects

“Reduction in drug intake was not effective due to the increased seizures, so the drug was maintained, along with potassium supplementation. In conclusion, the patient has been diagnosed with hypokalemia and iatrogenic hyperaldosteronism, rare in our outpatient practice.”

Tattoli et al. · From the abstract

Names Potassium and Topiramate together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Potassium, Topiramate, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.