NutriStack
Quetiapine and Valerian Root, a caution.
Valerian root has GABAergic and sedative properties that can produce additive CNS depression when combined with quetiapine. The combination may cause excessive drowsiness, dizziness, confusion, impaired motor coordination, and difficulty concentrating. Elderly patients are at increased risk for falls and respiratory depression. The interaction is pharmacodynamic rather than pharmacokinetic.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Quetiapine and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Valerian root has GABAergic and sedative properties that can produce additive CNS depression when combined with quetiapine. The combination may cause excessive drowsiness, dizziness, confusion, impaired motor coordination, and difficulty concentrating. Elderly patients are at increased risk for falls and respiratory depression. The interaction is pharmacodynamic rather than pharmacokinetic.
Mechanism. Valerian root contains valerenic acid and other compounds that modulate GABA-A receptor function, increasing GABAergic inhibition. Quetiapine's sedative effects are mediated through H1 histamine antagonism, alpha-1 adrenergic blockade, and some GABAergic activity. The combined CNS depression through multiple pathways creates additive or synergistic sedation.
Recommendation. Avoid combining valerian root with quetiapine unless approved by your prescriber. If using both, avoid hazardous activities requiring alertness. Start valerian at the lowest dose and monitor for excessive sedation. Elderly patients should be especially cautious. Report excessive drowsiness or confusion to your prescriber.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Quetiapine and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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