NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Quetiapine: what the published research says

PubMed indexes 8 records that name Alcohol and Quetiapine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Quetiapine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Alcohol and Quetiapine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effects of quetiapine on behavioral changes and expression of myelin proteins in a chronic alcohol dependence rat model.

Behavioural brain research · 2020 · PMID 32070690

Animal study

“Chronic quetiapine treatment alleviated the damage induced by chronic ethanol exposure with regard to learning and memory ability and to brain white matter. Thus, quetiapine appears to be a potentially promising pharmacotherapy for the treatment of alcohol use disorder.”

Han et al. · Authors' conclusion

Names both Alcohol and Quetiapine in its title.

Heavy Alcohol Drinking Associated Akathisia and Management with Quetiapine XR in Alcohol Dependent Patients.

Journal of addiction · 2016 · PMID 27847671

“Treatment with Quetiapine progressively lowered the occurrence of akathisia in alcohol dependent patients who do not show symptoms of depression. Quetiapine treatment lowered akathisia over time in heavy drinkers who had clinically significant symptoms of depression.”

Kurlawala et al. · From the abstract

Names both Alcohol and Quetiapine in its title.

Effects of risperidone, quetiapine and ziprasidone on ethanol withdrawal syndrome in rats.

Progress in neuro-psychopharmacology & biological psychiatry · 2011 · PMID 21168466

Human subjects

“Our results suggest that risperidone, quetiapine and ziprasidone had beneficial effects on EWS in rats. Thus, these drugs may be helpful for controlling withdrawal signs in ethanol-dependent patients.”

Celikyurt et al. · From the abstract

Names both Alcohol and Quetiapine in its title.

Quetiapine for treatment of alcohol dependence.

Journal of clinical psychopharmacology · 2004 · PMID 15349010

Research Support, U.S. Gov't, Non-P.H.S.Human subjects

“This study has the usual limitations of a retrospective review, including the lack of standardized assessments of alcohol use. The results of this study are consistent with the hypothesis that the use of quetiapine to improve disturbed sleep may help alcohol-dependent patients maintain abstinence, although decreased drinking may also be a result of improving posttraumatic stress disorder symptoms or of a direct action of quetiapine to reduce alcohol use.”

Monnelly et al. · From the abstract

Names both Alcohol and Quetiapine in its title.

Atypical Antipsychotic Drugs in Dual Disorders: Current Evidence for Clinical Practice.

Current pharmaceutical design · 2022 · PMID 35747956

Meta-AnalysisHuman subjects

“The findings highlight the use of SGA for the treatment of psychotic symptoms in comorbidity with substance use. Future studies on people with dual diagnosis and focused on long-term evaluations are warranted and need to investigate the efficacy of newly introduced molecules, such as partial D2 agonists and longacting injectable antipsychotics.”

Martinotti et al. · Authors' conclusion

Names Alcohol and Quetiapine together in an interaction, co-administration, or pharmacokinetic context.

Risk factors for clozapine-induced myocarditis and cardiomyopathy: A systematic review and meta-analysis.

Acta psychiatrica Scandinavica · 2022 · PMID 35067911

Meta-AnalysisSystematic ReviewHuman subjects

“Concurrent use of sodium valproate increases the odds of clozapine-induced myocarditis. Thus, clinicians should consider the temporary cessation of sodium valproate during the initial titration phase of clozapine.”

Vickers et al. · Authors' conclusion

Names Alcohol and Quetiapine together in an interaction, co-administration, or pharmacokinetic context.

Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose.

Clinical toxicology (Philadelphia, Pa.) · 2021 · PMID 34424785

Systematic ReviewHuman subjects

“This systematic review found heterogenous data. The higher GRADE data was focused on a few select poisonings, while studies that addressed patients with unknown and or mixed ingestions were hampered by low rates of clinically meaningful toxicity or death. Despite these limitations, they reported a benefit of activated charcoal beyond one hour in many clinical scenarios.”

Hoegberg et al. · Authors' conclusion

Names Alcohol and Quetiapine together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Quetiapine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.