What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Resveratrol + Warfarin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Resveratrol and Warfarin, a caution.

Q: Can I take Resveratrol and Warfarin together?

Possibly, but with caution. Resveratrol and Warfarin have a documented caution-tier interaction. Resveratrol inhibits CYP2C9, the main enzyme that clears the more potent S-enantiomer of warfarin, and also inhibits BCRP-mediated efflux. In animal models this raises plasma warfarin AUC and significantly increases INR. Resveratrol additionally inhibits platelet COX-1 and thromboxane A2, adding a pharmacodynamic bleeding risk. Combined effects can amplify warfarin's anticoagulation.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Resveratrol inhibits CYP2C9, the main enzyme that clears the more potent S-enantiomer of warfarin, and also inhibits BCRP-mediated efflux. In animal models this raises plasma warfarin AUC and significantly increases INR. Resveratrol additionally inhibits platelet COX-1 and thromboxane A2, adding a pharmacodynamic bleeding risk. Combined effects can amplify warfarin's anticoagulation.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Resveratrol and Warfarin
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Resveratrol inhibits CYP2C9, the main enzyme that clears the more potent S-enantiomer of warfarin, and also inhibits BCRP-mediated efflux. In animal models this raises plasma warfarin AUC and significantly increases INR. Resveratrol additionally inhibits platelet COX-1 and thromboxane A2, adding a pharmacodynamic bleeding risk. Combined effects can amplify warfarin's anticoagulation.

Mechanism. Resveratrol and its conjugated metabolites inhibit CYP2C9 and BCRP, increasing S-warfarin systemic exposure. Independently, resveratrol inhibits platelet COX-1 and thromboxane A2 generation, adding antiplatelet activity to warfarin's anticoagulation.

Recommendation. Avoid resveratrol supplements (typically 100-500 mg/day) while on warfarin. If you choose to take it, keep the dose constant and ask your anticoagulation clinic to recheck INR within 1-2 weeks of starting or stopping.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Resveratrol and Warfarin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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