NutriStack
Sertraline and Tramadol, contraindicated.
Concurrent use of SSRIs and tramadol significantly increases the risk of serotonin syndrome, a potentially life-threatening condition characterized by agitation, hyperthermia, tachycardia, and neuromuscular abnormalities.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Sertraline and Tramadol
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Concurrent use of SSRIs and tramadol significantly increases the risk of serotonin syndrome, a potentially life-threatening condition characterized by agitation, hyperthermia, tachycardia, and neuromuscular abnormalities.
Mechanism. Tramadol inhibits serotonin reuptake in addition to its opioid activity. Combined with SSRI serotonin reuptake inhibition, excessive serotonergic activity can precipitate serotonin syndrome.
Recommendation. Avoid concurrent use. If both are necessary, use the lowest effective doses with close monitoring for serotonin syndrome symptoms. Seek immediate medical attention for fever, agitation, or muscle rigidity.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Sertraline and Tramadol are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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