NutriStack
Vitamin A and Vitamin K2, a synergy.
Vitamins A and K2 contribute to bone and calcium handling alongside vitamin D, supporting balanced mineralization at nutritional intakes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin A and Vitamin K2
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Vitamins A and K2 contribute to bone and calcium handling alongside vitamin D, supporting balanced mineralization at nutritional intakes.
Mechanism. Both are fat-soluble vitamins; vitamin A acts through retinoid nuclear receptors that heterodimerize with the vitamin D receptor, intersecting the vitamin D and vitamin K dependent pathways that govern osteocalcin activity and bone mineralization.
Recommendation. Reasonable to take together at nutritional doses; avoid high-dose preformed vitamin A (retinol), which at excess can adversely affect bone and antagonize vitamin D signaling.
Sources (2)
- Maresz K, Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health, Integrative Medicine, 2015
- Booth SL, Roles for Vitamin K beyond coagulation, Annual Review of Nutrition, 2009
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin A and Vitamin K2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
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