From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Vitamin K2 is sometimes used for bone matrix protein carboxylation and may overlap with bone-health goals.
Mechanism. Vitamin K-dependent carboxylation of osteocalcin may support bone mineralization.
Recommendation. Use as adjunctive nutrition support only; it does not offset raloxifene clot or stroke risk.
Stack Score
How it moves the number.
Effect on the composite score
If both Raloxifene and Vitamin K2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1LeBoff MS et al. Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporosis International. 2022.Needs sourceNo link