Supplement × Prescription·a synergy·Strong evidence

Calcium + Raloxifene

Synergy Strong evidence

Adequate calcium intake supports bone mineralization while raloxifene reduces bone resorption.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Synergy
Evidence
Strong
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyStrong evidence

What is happening. Adequate calcium intake supports bone mineralization while raloxifene reduces bone resorption.

Mechanism. Calcium provides substrate for bone mineral while raloxifene modulates estrogen receptor effects in bone.

Recommendation. Use diet first when possible; supplement only enough to meet recommended intake and avoid excessive calcium.

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium and Raloxifene are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Raloxifene Hydrochloride Tablets US Prescribing Information. 2026.Needs sourceNo link

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