NutriStack
Vitamin K1 and Vitamin K2 MK-4, a synergy.
K1 primarily supports coagulation while K2 (MK-7) directs calcium to bones. Complementary roles in vitamin K metabolism.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin K1 and Vitamin K2 MK-4
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. K1 primarily supports coagulation while K2 (MK-7) directs calcium to bones. Complementary roles in vitamin K metabolism.
Mechanism. K1 (phylloquinone) activates hepatic clotting factors. K2 (menaquinone-7) has greater bioavailability for extrahepatic tissues, activating osteocalcin and MGP.
Recommendation. Both forms are beneficial. K2 (MK-7) has a longer half-life and better extrahepatic distribution than K1.
Sources (1)
- Schurgers LJ et al. Vitamin K–containing dietary supplements. Blood. 2007
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin K1 and Vitamin K2 MK-4 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.