NutriStack
Symptom·Appearance·Reviewed May 30, 2026
Supplements for Melasma (hormonal facial pigmentation).
When melasma (hormonal facial pigmentation) is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Pine Bark ExtractLimited74% match
Pycnogenol-type pine bark extract is an antioxidant that has reduced melasma pigment and area in small clinical trials.
SuggestedStandardized pine bark extract (Pycnogenol), about 75 mg daily - 02Vitamin CLimited70% match
Vitamin C inhibits tyrosinase and brightens pigment, both orally as an antioxidant and topically.
SuggestedTopical L-ascorbic acid serum plus oral vitamin C 500 mg - 03Grape Seed ExtractLimited62% match
Proanthocyanidins in grape seed extract have lightened melasma in small studies via antioxidant and tyrosinase-modulating effects.
SuggestedGrape seed extract standardized to proanthocyanidins, around 150 to 300 mg daily - 04AstaxanthinLimited55% match
As a potent antioxidant carotenoid it may reduce UV-driven oxidative stress that aggravates melasma pigmentation.
SuggestedAstaxanthin 4 to 12 mg daily with a fat-containing meal - 05L-GlutathioneLimited50% match
Glutathione shifts melanin toward lighter pheomelanin and inhibits tyrosinase, a basis for its skin-lightening reputation.
SuggestedOral L-Glutathione 250 to 500 mg, often with vitamin C
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