NutriStack
Cannabis (THC-Dominant) and Valerian Root, a caution.
Valerian and THC-dominant cannabis both have sedative properties, so combining them can cause additive central nervous system depression and excessive drowsiness.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Cannabis (THC-Dominant) and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Valerian and THC-dominant cannabis both have sedative properties, so combining them can cause additive central nervous system depression and excessive drowsiness.
Mechanism. Valerian appears to enhance GABAergic signaling to promote sedation, which adds to the independent CNS depressant effects of THC.
Recommendation. Best avoided together; the combination can produce stronger than expected sedation. Do not drive or operate machinery, and seek medical advice if combined with other CNS depressants.
Sources (1)
- Bent S et al, Valerian for sleep: a systematic review and meta-analysis, American Journal of Medicine, 2006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cannabis (THC-Dominant) and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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