NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Erythromycin and Probiotics: what the published research says

PubMed indexes 7 records that name Erythromycin and Probiotics together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Erythromycin and Probiotics. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

7 studies naming Erythromycin and Probiotics.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains.

International journal of microbiology · 2018 · PMID 30534155

“Thus, in the present study, L. fermentum was not implicated in the spread of erythromycin and tetracycline resistance, but still these strains pose the threat to the environment and human health because they harbored erythromycin and tetracycline resistance genes in their plasmids and therefore should not be used in foods and probiotics.”

Anisimova et al. · From the abstract

Names both Erythromycin and Probiotics in its title.

A Gene Homologous to rRNA Methylase Genes Confers Erythromycin and Clindamycin Resistance in Bifidobacterium breve.

Applied and environmental microbiology · 2018 · PMID 29500262

Human subjects

“This gene seems to be very uncommon in other bifidobacteria and in the gut microbiomes of both adults and infants. Even though conjugation experiments showed the absence of transferability under in vitro conditions, it has been predicted to be located in a putative genomic island recently acquired by specific bifidobacterial strains.”

Martínez et al. · From the abstract

Names both Erythromycin and Probiotics in its title.

Susceptibility to tetracycline and erythromycin of Lactobacillus paracasei strains isolated from traditional Italian fermented foods.

International journal of food microbiology · 2010 · PMID 20005592

Human subjects

“Since "commensal" bacteria, which L. paracasei belongs to, may play an active role in the spreading of antibiotic resistance, a series of measures inspired from a principle of precaution should be taken before they are used as commercial starters or probiotic cultures in food products, complemented by a more prudent use of antibiotics in agriculture, veterinary, and human medicine.”

Comunian et al. · From the abstract

Names both Erythromycin and Probiotics in its title.

Effects of erythromycin-inactivating Lactobacillus crop flora on blood levels of erythromycin given orally to chicks.

Journal of veterinary pharmacology and therapeutics · 1984 · PMID 6708166

Animal study

“Five groups of broiler chickens of different age originating from three farms all possessed an erythromycin-degrading crop flora. In none of these were therapeutic blood levels attained when erythromycin was given in the drinking water.”

Devriese et al. · From the abstract

Names both Erythromycin and Probiotics in its title.

Comparative evaluation of yogurt and low-fat cheddar cheese as delivery media for probiotic Lactobacillus casei.

Journal of food science · 2008 · PMID 18803722

Comparative Study

“As a whole, these data showed that low-fat Cheddar cheese is a viable delivery food for probiotic L. casei because it allowed for good survival during storage and helped protect cells against the very low pH that will be encountered during stomach transit.”

Sharp et al. · From the abstract

Names Erythromycin and Probiotics together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Erythromycin, Probiotics, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.