What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Ginkgo Biloba + Voriconazole pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Emerging evidence

Ginkgo Biloba + Voriconazole

Q: Can I take Ginkgo Biloba and Voriconazole together?

Possibly, but with caution. Ginkgo Biloba and Voriconazole have a documented caution-tier interaction. Ginkgo biloba has been reported to modestly induce CYP2C19 in some pharmacokinetic studies, and CYP2C19 is a major pathway for voriconazole metabolism (with large genetic variability among individuals). Concurrent ginkgo could lower voriconazole concentrations in some patients, contributing to subtherapeutic antifungal exposure. Ginkgo also has antiplatelet activity, which is a separate consideration in patients who may be thrombocytopenic from infection or chemotherapy.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Ginkgo biloba has been reported to modestly induce CYP2C19 in some pharmacokinetic studies, and CYP2C19 is a major pathway for voriconazole metabolism (with large genetic variability among individuals). Concurrent ginkgo could lower voriconazole concentrations in some patients, contributing to subtherapeutic antifungal exposure. Ginkgo also has antiplatelet activity, which is a separate consideration in patients who may be thrombocytopenic from infection or chemotherapy.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Ginkgo Biloba and Voriconazole

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Ginkgo biloba has been reported to modestly induce CYP2C19 in some pharmacokinetic studies, and CYP2C19 is a major pathway for voriconazole metabolism (with large genetic variability among individuals). Concurrent ginkgo could lower voriconazole concentrations in some patients, contributing to subtherapeutic antifungal exposure. Ginkgo also has antiplatelet activity, which is a separate consideration in patients who may be thrombocytopenic from infection or chemotherapy.

Mechanism. Ginkgo constituents may induce CYP2C19, increasing voriconazole metabolism and lowering plasma levels; ginkgo's antiplatelet flavonoid and terpene lactone activity is an independent bleeding-risk concern.

Recommendation. Avoid ginkgo biloba during voriconazole therapy unless your prescriber approves it. If it cannot be avoided, ensure voriconazole trough levels are monitored, since reduced concentrations risk antifungal failure. Report any unusual bruising or bleeding.

Stack Score

How it moves the number.

Effect on the composite score

If both Ginkgo Biloba and Voriconazole are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Yin OQ, Tomlinson B, Waye MM, et al. Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics. 2004.Needs sourceNo link
2Theuretzbacher U, Ihle F, Derendorf H. Pharmacokinetic/pharmacodynamic profile of voriconazole. Clin Pharmacokinet. 2006.Needs sourceNo link

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