NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Hesperidin and Iron: what the published research says

PubMed indexes 5 records that name Hesperidin and Iron together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Hesperidin and Iron. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

5 studies naming Hesperidin and Iron.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Genetic basis of the historical iron-accumulating dgl and brz mutants in pea.

The Plant journal : for cell and molecular biology · 2024 · PMID 37882414

“Identification of the mutated genes rationalizes many of the previously described phenotypes and provides new insights into shoot-to-root signaling of iron deficiency. Furthermore, the non-lethal mutations in these essential genes suggest new strategies for biofortification of crops with iron.”

Harrington et al. · From the abstract

Names both Hesperidin and Iron in its title.

Iron Oxide Nanoparticles: Physicochemical Characteristics and Historical Developments to Commercialization for Potential Technological Applications.

ACS biomaterials science & engineering · 2021 · PMID 34786932

Review

“Additionally, in industrial sectors IONP-based fluids (ferrofluids) have been marketed in electronic and mechanical devices for some time. This review explores the historical evolution of IONPs to their current state in biomedical and industrial applications.”

Etemadi et al. · From the abstract

Names both Hesperidin and Iron in its title.

New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications.

International journal of molecular sciences · 2021 · PMID 34074010

ReviewHuman subjects

“The interactions of the KHP iron complexes with natural chelators, drugs, metal ions, proteins, and other molecules appear to affect the pharmacological and metabolic effects of both iron and the KHP chelators. A new era in the treatment of IDA and other possible clinical applications, such as theranostic and anticancer formulations and metal radiotracers in diagnostic medicine, are envisaged from the introduction of maltol, KHP, and similar lipophilic chelators.”

Kontoghiorghes et al. · From the abstract

Names both Hesperidin and Iron in its title.

Nonheme-iron histochemistry for light and electron microscopy: a historical, theoretical and technical review.

Archives of histology and cytology · 2007 · PMID 17558140

ReviewHuman subjects

“Although the above histochemical methods have advantages for visualizing iron by conventional light and electron microscopy, the quantitative estimation of iron is not easy. Recent methods depending on the quenching of fluorescent divalent metal indicators by Fe(2+) and dequenching by divalent metal chelators have enabled the quantitative estimation of chelatable Fe(2+) in isolated viable cells.”

Meguro et al. · From the abstract

Names both Hesperidin and Iron in its title.

The concept of iron bioavailability and its assessment.

European journal of nutrition · 1999 · PMID 10352945

Comparative StudyReviewHuman subjects

“Finally, some arithmetic models were described. These models were based on data from iron bioavailability studies and could predict the bioavailability of iron from a meal.”

Wienk et al. · From the abstract

Names Hesperidin and Iron together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Hesperidin, Iron, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.