Supplement × Prescription·timing-sensitive·Moderate evidence

Ibandronate + Zinc

Timing Sensitive Moderate evidence

Zinc may bind oral ibandronate and reduce absorption if taken too close.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Timing Sensitive
Evidence
Moderate
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveModerate evidence

What is happening. Zinc may bind oral ibandronate and reduce absorption if taken too close.

Mechanism. Cation chelation of bisphosphonate drug.

Recommendation. Separate zinc from ibandronate by at least 60 minutes, and ideally take zinc later with food.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation
60
Stack Score

How it moves the number.

Effect on the composite score

If both Ibandronate and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Ibandronate Sodium Tablets US Prescribing Information. 2026.Needs sourceNo link

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