Supplement × Prescription·a synergy·Strong evidence

Ibandronate + Vitamin D3

Synergy Strong evidence

Adequate vitamin D supports safe and effective antiresorptive therapy by reducing hypocalcemia risk and supporting bone mineralization.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Synergy
Evidence
Strong
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyStrong evidence

What is happening. Adequate vitamin D supports safe and effective antiresorptive therapy by reducing hypocalcemia risk and supporting bone mineralization.

Mechanism. Vitamin D improves calcium absorption and mineral homeostasis while ibandronate suppresses bone resorption.

Recommendation. Correct vitamin D deficiency before or during therapy under clinician guidance.

Stack Score

How it moves the number.

Effect on the composite score

If both Ibandronate and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1LeBoff MS et al. Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporosis International. 2022.Needs sourceNo link

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