From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveStrong evidence
What is happening. Iron can reduce oral Minocycline absorption when taken together.
Mechanism. Polyvalent cations can form poorly absorbed complexes in the gut or otherwise reduce oral antibiotic bioavailability.
Recommendation. Separate minocycline from iron supplements by several hours to avoid reduced absorption.
Stack Score
How it moves the number.
Effect on the composite score
If both Iron and Minocycline are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1DailyMed. Minocycline US prescribing information. 2026.Needs sourceNo link