NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Iron and Soy Isoflavones: what the published research says

PubMed indexes 4 records that name Iron and Soy Isoflavones together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Iron and Soy Isoflavones. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Iron and Soy Isoflavones.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effect of quercetin and genistein on copper- and iron-induced lipid peroxidation in methyl linolenate.

Journal of applied toxicology : JAT · 2003 · PMID 12975775

Comparative Study

“The data suggest that the combined flavonoids offered better protection than the single treatments and this may be attributed to the better radical scavenging or increased chelating capabilities of the combined over the single treatments. The differences in peroxide levels for the single treatment of quercetin compared with the genistein-treated samples may reflect the structural differences between these compounds in combating oxidative stress.”

Boadi et al. · From the abstract

Names both Iron and Soy Isoflavones in its title.

Genistein up-regulates the iron efflux system in glial cells.

Neuroscience letters · 2010 · PMID 20056127

Human subjects

“Genistein significantly increased iron export through estrogen receptor-beta-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP.”

Persichini et al. · From the abstract

Names both Iron and Soy Isoflavones in its title.

Genistein protects primary cortical neurons from iron-induced lipid peroxidation.

Molecular and cellular biochemistry · 2003 · PMID 12841651

Animal study

“Also, genistein (100 microM) led to a relatively higher SOD level than that in iron treatment although no significant difference was found. The findings imply that the antioxidative effect of genistein is partly associated with its neuroprotective function.”

Ho et al. · From the abstract

Names both Iron and Soy Isoflavones in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Iron, Soy Isoflavones, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.