NutriStack
L-Citrulline and Lisinopril, a synergy.
L-Citrulline is converted to arginine in the kidney and produces sustained increases in nitric oxide. A meta-analysis of clinical trials reported reductions of about 4-7 mm Hg systolic and 3-4 mm Hg diastolic blood pressure. Combined with lisinopril the effects are additive and well tolerated, though mild hypotension is possible if blood pressure is already at goal.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Citrulline and Lisinopril
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. L-Citrulline is converted to arginine in the kidney and produces sustained increases in nitric oxide. A meta-analysis of clinical trials reported reductions of about 4-7 mm Hg systolic and 3-4 mm Hg diastolic blood pressure. Combined with lisinopril the effects are additive and well tolerated, though mild hypotension is possible if blood pressure is already at goal.
Mechanism. L-Citrulline is recycled to arginine via the kidney, providing sustained substrate for endothelial nitric oxide synthase. ACE inhibition independently raises bradykinin and nitric oxide. Combined endothelial effects produce additive vasodilation.
Recommendation. L-Citrulline 3-6 g/day is a reasonable add-on; monitor home blood pressure after starting and tell your prescriber. Avoid combination with sildenafil or tadalafil without medical guidance.
Sources (2)
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials. Curr Hypertens Rep. 2018;20(11):98. PMID 30284051
- Komers R, Komersova K, Kazdova L, Ruzickova J, Pelikanova T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-9. PMID 10678543
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Citrulline and Lisinopril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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