Supplement × Prescription·timing-sensitive·Moderate evidence

Magnesium Glycinate + Sucralfate

Timing Sensitive Moderate evidence

Magnesium products may interfere with sucralfate binding behavior and can reduce the predictability of other oral drug absorption.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Pair type
Timing Sensitive
Evidence
Moderate
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveModerate evidence

What is happening. Magnesium products may interfere with sucralfate binding behavior and can reduce the predictability of other oral drug absorption.

Mechanism. Divalent cations and antacid effects can alter luminal binding and local acidity.

Recommendation. Separate magnesium from sucralfate by at least 2 hours; avoid magnesium-containing antacids close to sucralfate unless directed.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation
120
Stack Score

How it moves the number.

Effect on the composite score

If both Magnesium Glycinate and Sucralfate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1McCarthy DM. Drug interactions with sucralfate. American Journal of Medicine. 1991.Needs sourceNo link

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